Two related research projects focusing on adolescent psychological adjustment (e.g., substance abuse, depression, and anxiety) that Dr. Ohannessian is involved with are the COGA Project and the RISK Project.
THE COLLABORATIVE STUDY ON THE GENETICS OF ALCOHOLISM (COGA)
(Funded by the National Institutes of Health – grant #U10AA08403)
COGA is a large-scale, extended pedigree family study designed to follow alcoholics and their families over time. COGA was designed to identify susceptibility genes for alcohol dependence. Probands, controls, and their biological family members are tracked over time; to date, most subjects have been assessed three times over the past 15 years. All COGA participants receive a battery of tests including an extensive psychiatric interview (the SSAGA), neuropsychological testing, EEG/ERP testing, and a series of self-report questionnaires. The COGA project includes six sites (Indiana University; State University of New York; University of California at San Diego; University of Connecticut; University of Iowa; and Washington University in St. Louis). Data collection began in 1989 and is currently ongoing.
(Funded by the National Institutes of Health – grant #5P50-AA-3510; PI – Dr. Victor Hesselbrock)
The RISK project was designed to longitudinally follow offspring of alcohol and/or drug dependent fathers over time. The study includes four groups: youth with fathers with alcohol dependence, youth with fathers with cocaine dependence, youth with fathers with heroin dependence, and youth with fathers without a substance dependence problem. The RISK project began in 1993 and is currently ongoing. At Time 1, the diverse inner city sample included 200 15-19 year-old adolescents (62% girls; 68% Caucasian) and their fathers. The youth are followed up in 5 year intervals. At the last assessment, they were 25-29 years old. At all times of measurement, participants complete a clinical psychiatric interview in order to obtain psychiatric diagnoses and information relating to substance use, along with a battery of self-report questionnaires.